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Aminoglycoside‐Resistance Mechanisms for Cystic FibrosisPseudomonas aeruginosaIsolates Are Unchanged by Long‐Term, Intermittent, Inhaled Tobramycin Treatment

1 Mar 2000

Abstract excerpt

Aminoglycoside-resistance mechanisms were characterized in Pseudomonas aeruginosa isolates from cystic fibrosis (CF) patients during a recent clinical trial of inhaled tobramycin. Impermeability, in which bacteria have reduced susceptibility to all aminoglycosides, was the predominant mode of resistance in isolates obtained both before and after 6 months of cyclic treatment with tobramycin or placebo administered...

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PMID: 10720551
DOI: 10.1086/315312

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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