Article
The ret/PTC mutations are common in sporadic papillary thyroid carcinoma of children and young adults.
The Journal of clinical endocrinology and metabolism - 1 Mar 2000
Fenton C L, Lukes Y, Nicholson D, Dinauer C A, Francis G L, Tuttle R M
Abstract excerpt
The ret/PTC rearrangements (PTC-1, PTC-2, and PTC-3) are characteristic of papillary thyroid cancer (PTC). In adults, PTC-1 is common and may be associated with an aggressive clinical course. The incidence and significance of ret/PTC mutations are less well understood in children. We examined spontaneous PTC from 33 patients (23 females and 10 males) with a median age of 18 yr (range, 6-21 yr) and a median...
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