Article
Behavioral deficits in APP(V717F) transgenic mice deficient for the apolipoprotein E gene.
Neuroreport - 28 Feb 2000
Dodart J C, Mathis C, Bales K R, Paul S M, Ungerer A
Abstract excerpt
Both the beta-amyloid precursor protein (APP) and the apoliprotein E (apoE) genes are involved in the pathogenesis of Alzheimer's disease (AD). We previously showed that mice over-expressing a human mutated form of APP (APP(V717F)) display age-dependent recognition memory deficits associated with the progression of amyloid deposition. Here, we asked whether 10- to 12-month-old APP(V717F) mice lacking the apoE...
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