Article
A CA repeat polymorphism of the IFN-gamma gene is associated with susceptibility to type 1 diabetes.
Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research - 1 Feb 2000
Jahromi M, Millward A, Demaine A
Abstract excerpt
Recent studies have shown that loci outside the HLA region are involved in determining susceptibility to type 1 diabetes. Polymorphisms in the coding and noncoding regions of the genes encoding cytokines may be involved in modulating the immune response to self and nonself antigens. There is increasing evidence that an imbalance and disruption of the Thl and Th2 T cell subsets play a key role in the development...
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