Article
In vitro production of IFN-gamma correlates with CA repeat polymorphism in the human IFN-gamma gene.
European journal of immunogenetics : official journal of the British Society for Histocompatibility and Immunogenetics - 1 Feb 1999
Pravica V, Asderakis A, Perrey C, Hajeer A, Sinnott P J, Hutchinson I V
Abstract excerpt
The DNA sequence of the human IFN-gamma gene shows the presence of a variable-length CA repeat in the first intron of the gene. We investigated the allele distribution of this microsatellite region in 164 unrelated healthy individuals, and the association with interferon-gamma (IFN-gamma) production. In vitro production of IFN-gamma showed a significant correlation with the presence of allele #2.
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