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Article

Mutations in sixth transmembrane domain of AQP2 inhibit its translocation induced by vasopression.

American journal of physiology. Renal physiology - 1 Mar 2000

Yamashita Y, Hirai K, Katayama Y, Fushimi K, Sasaki S, Marumo F

Abstract excerpt

Vasopression-induced phosphorylation of serine 256 of the aquaporin-2 (AQP2) water channel triggers translocation of the protein from cystolic reservoir vesicles to the apical membrane of collecting duct principal cells. Dileucine motifs are located in the sixth transmembrane domain (6TM) of AQP2 and are known as the signal sequence for internalization, sorting from the trans-Golgi network to endosomes/lysosomes,...

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Source

Identifiers

PMID: 10710544
DOI: 10.1152/ajprenal.2000.278.3.F395

Genes

AQP2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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