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Article

Characterization of the putative phosphorylation sites of the AQP2 C terminus and their role in AQP2 trafficking in LLC-PK1 cells.

American journal of physiology. Renal physiology - 15 Oct 2015

Arthur Julian, Huang Jianmin, Nomura Naohiro, Jin William W, Li Wei, Cheng Xiang, Brown Dennis, Lu Hua Jenny

Abstract excerpt

Vasopressin (VP) stimulates a signaling cascade that results in phosphorylation and apical membrane accumulation of aquaporin-2 (AQP2), leading to water reabsorption by kidney collecting ducts. However, the roles of most C-terminal phosphorylation events in stimulated and constitutive AQP2 recycling are incompletely understood. Here, we generated LLC-PK1 cells containing point mutations of all potential...

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Identifiers

PMID: 26290367
DOI: 10.1152/ajprenal.00152.2015
PMCID: PMC4609919

Genes

AQP2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Characterization of the putative phosphorylation sites of the AQP2 C terminus and their role in AQP2 trafficking in LLC-PK1 cells.PMID 26290367Read ↗

Differential, phosphorylation dependent trafficking of AQP2 in LLC-PK1 cells.Semantic proximity Read ↗

Role of multiple phosphorylation sites in the COOH-terminal tail of aquaporin-2 for water transport: evidence against channel gating.Semantic proximity Read ↗

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Missorting of the Aquaporin-2 mutant E258K to multivesicular bodies/lysosomes in dominant NDI is associated with its monoubiquitination and increased phosphorylation by PKC but is due to the loss of E258.Semantic proximity Read ↗

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