[Insulin resistance and beta 3-adrenergic receptor function].

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Article

[Insulin resistance and beta 3-adrenergic receptor function].

Nihon rinsho. Japanese journal of clinical medicine - 1 Feb 2000

Kobayashi I, Ishigami T, Umemura S

Abstract excerpt

Beta 3-adrenergic receptors are expressed predominantly on white and brown adipocytes. Activation of the receptor stimulates lipolysis in adipose tissues and increases energy expenditure by thermogenesis in brown adipocytes. It is proposed that dysfunction of beta 3-adrenergic receptor result to obesity and insulin resistance. Trp64Arg mutation of human beta 3-adrenergic receptor gene is found frequently in Pima...

Topics

Adipocytes
Animals
Diabetes Mellitus, Type 2
Energy Metabolism
Humans
Insulin Resistance
Lipolysis
Mutation
Obesity
Receptors, Adrenergic, beta
Receptors, Adrenergic, beta-3

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PMID: 10707554

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