Article
Role of activator protein-1 in TCR-mediated regulation of the murine fasl promoter.
Journal of immunology (Baltimore, Md. : 1950) - 15 Mar 2000
Matsui K, Xiao S, Fine A, Ju S T
Abstract excerpt
The present study demonstrates that transcription factor interactions are important in regulating the murine fasl promoter following TCR-mediated activation. We used DNase I-footprinting, EMSAs, and transient transfection assays to identify the minimal TCR signal-responsive region within the fasl promoter. This region contains the previously identified binding sites for NF-kappaB and Egr and the AP-1 site...
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