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Article

Rnx deficiency results in congenital central hypoventilation.

Nature genetics - 1 Mar 2000

Shirasawa S, Arata A, Onimaru H, Roth K A, Brown G A, Horning S, Arata S, Okumura K, Sasazuki T, Korsmeyer S J

Abstract excerpt

The genes Tlx1 (Hox11), Enx (Hox11L2, Tlx-2) and Rnx (Hox11L2, Tlx-3) constitute a family of orphan homeobox genes. In situ hybridization has revealed considerable overlap in their expression within the nervous system, but Rnx is singularly expressed in the developing dorsal and ventral region of the medulla oblongata. Tlx1-deficient and Enx-deficient mice display phenotypes in tissues where the mutated gene is...

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PMID: 10700185
DOI: 10.1038/73516

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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