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Article

NALCN Dysfunction as a Cause of Disordered Respiratory Rhythm With Central Apnea.

Pediatrics - 1 Apr 2018

Campbell Jamie, FitzPatrick David R, Azam Tara, Gibson Neil A, Somerville Laura, Joss Shelagh K, Urquhart Don S

Abstract excerpt

The sodium leak channel nonselective protein (NALCN) is a regulator of the pacemaker neurons that are responsible for rhythmic behavior (including respiration), maintaining the resting membrane potential, and are required for action potential production. NALCN-null mice show early death associated with disrupted respiratory rhythms, characterized by frequent and profound apneas. We report 3 children (2 siblings)...

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Source

Identifiers

PMID: 29610177
DOI: 10.1542/peds.2017-0026

Genes

NALCN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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