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Article

Familial Sex Reversal: A Review

1 Feb 2000

Abstract excerpt

Since 1905, it has been recognized that a gene on the Y chromosome, originally termed TDF (for “testes-determining factor”) acted in a dominant fashion to promote male sexual development (1). In 1990, the SRY (sex-determining region Y) gene was identified as TDF (2). This gene was cloned, and its identity was confirmed by studying individuals with sex reversal (phenotypic sex of one type, genetic sex of the...

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Identifiers

PMID: 10690846
DOI: 10.1210/jcem.85.2.6418

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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