Article
Germline CDKN2A mutation implicated in predisposition to multiple myeloma.
Blood - 1 Mar 2000
Dilworth D, Liu L, Stewart A K, Berenson J R, Lassam N, Hogg D
Abstract excerpt
Germline mutations of the CDKN2A (p16(INK4A)) tumor suppressor gene predispose patients to melanoma and pancreatic carcinoma. In contrast, mutations of the murine CDKN2A gene predispose BALB/c mice to pristane-induced plasmacytoma. We describe here a family in which a germline mutation of CDKN2A is present in 4 individuals who developed melanoma as well as in a fifth family member who is suffering from multiple...
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