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Article

Germline CDKN2A Mutations in Childhood Melanoma

1 Oct 1997

Abstract excerpt

Cutaneous melanoma, primarily a disease of adulthood, does occur in children and displays similar biologic behaviors, including invasion, metastasis, and death ( 1 ). The proposition that those who develop melanoma during childhood harbor a strong predisposition to melanocyte neoplasia is consistent with Knudson's hypothesis that cancers arising in the very young may result from mutations to key regulatory genes...

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PMID: 9326917
DOI: 10.1093/jnci/89.19.1460

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