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Article

Virus-induced neuronal apoptosis blocked by the herpes simplex virus latency-associated transcript.

Science (New York, N.Y.) - 25 Feb 2000

Perng G C, Jones C, Ciacci-Zanella J, Stone M, Henderson G, Yukht A, Slanina S M, Hofman F M, Ghiasi H, Nesburn A B, Wechsler S L

Abstract excerpt

Latent infections with periodic reactivation are a common outcome after acute infection with many viruses. The latency-associated transcript (LAT) gene is required for wild-type reactivation of herpes simplex virus (HSV). However, the underlying mechanisms remain unclear. In rabbit trigeminal ganglia, extensive apoptosis occurred with LAT(-) virus but not with LAT(+) viruses. In addition, a plasmid expressing LAT...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 10688801
DOI: 10.1126/science.287.5457.1500

Genes

LAT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Virus-induced neuronal apoptosis blocked by the herpes simplex virus latency-associated transcript.PMID 10688801Read ↗

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