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Article

Cellular FLIP can substitute for the herpes simplex virus type 1 latency-associated transcript gene to support a wild-type virus reactivation phenotype in mice.

Journal of neurovirology - 1 Oct 2008

Jin Ling, Carpenter Dale, Moerdyk-Schauwecker Megan, Vanarsdall Adam L, Osorio Nelson, Hsiang Chinhui, Jones Clinton, Wechsler Steven L

Abstract excerpt

Latency-associated transcript (LAT) deletion mutants of herpes simplex virus type 1 (HSV-1) have reduced reactivation phenotypes. Thus, LAT plays an essential role in the latency-reactivation cycle of HSV-1. We have shown that LAT has antiapoptosis activity and demonstrated that the chimeric virus, dLAT-cpIAP, resulting from replacing LAT with the baculovirus antiapoptosis gene cpIAP, has a wild-type HSV-1...

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Source

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Identifiers

PMID: 18989818
DOI: 10.1080/13550280802216510
PMCID: PMC2980827

Genes

LAT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Cellular FLIP can substitute for the herpes simplex virus type 1 latency-associated transcript gene to support a wild-type virus reactivation phenotype in mice.PMID 18989818Read ↗

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