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Productive Replication of Human Adenoviruses in Mouse Epidermal Cells

15 Mar 2000

Abstract excerpt

In contrast to most cells of mouse origin, cell lines derived from mouse epidermis are permissive for replication of human adenovirus type 5. The extent of epidermal cell differentiation correlated with the level of E1A expression and virus replication. Mouse epidermal cells may provide useful models for cancer therapy using replication-competent human adenoviruses.

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PMID: 10684307
DOI: 10.1128/jvi.74.6.2895-2899.2000

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