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Identification of a gene at 11q23 encoding a guanine nucleotide exchange factor: Evidence for its fusion with <i>MLL</i> in acute myeloid leukemia

11 Feb 2000

Abstract excerpt

We have identified a gene at 11q23, telomeric to MLL, that encodes a guanine nucleotide exchange factor (GEF). This gene is transcribed into a 9.5-kb mRNA containing a 4.6-kb ORF. By Northern analysis, it was found to be expressed in all human tissues examined including peripheral blood leukocytes, spleen, prostate, testis, ovary, small intestine, colon, and minimally in thymus. Analysis of the predicted protein...

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PMID: 10681437
DOI: 10.1073/pnas.040569197

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Related research

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Research trail→

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Identification of a gene at 11q23 encoding a guanine nucleotide exchange factor: Evidence for its fusion with <i>MLL</i> in acute myeloid leukemiaPMID 10681437Read ↗

<i>MSF</i> (MLL septin-like fusion), a fusion partner gene of <i>MLL,</i> in a therapy-related acute myeloid leukemia with a t(11;17)(q23;q25)Semantic proximity Read ↗

Identification of a gene, MLL, that spans the breakpoint in 11q23 translocations associated with human leukemias.Semantic proximity Read ↗

Leukemia-associated Rho Guanine Nucleotide Exchange Factor, a Dbl Family Protein Found Mutated in Leukemia, Causes Transformation by Activation of RhoASemantic proximity Read ↗

Regulation of Leukaemia Associated Rho GEF (LARG/ARHGEF12)Semantic proximity Read ↗

ABI-1, a Human Homolog to Mouse Abl-Interactor 1, Fuses theMLL Gene in Acute Myeloid Leukemia With t(10;11)(p11.2;q23)Semantic proximity Read ↗

The human <i>GRAF</i> gene is fused to <i>MLL</i> in a unique t(5;11)(q31;q23) and both alleles are disrupted in three cases of myelodysplastic syndrome/acute myeloid leukemia with a deletion 5qSemantic proximity Read ↗

AF6q21, a Novel Partner of the MLL Gene in t(6; 11)(q21; q23), Defines a Forkhead Transcriptional Factor SubfamilySemantic proximity Read ↗

DNA structural properties of AF9 are similar to MLL and could act as recombination hot spots resulting in MLL/AF9 translocations and leukemogenesisSemantic proximity Read ↗

LARG at chromosome 11q23 has functional characteristics of a tumor suppressor in human breast and colorectal cancerSemantic proximity Read ↗

The human formin-binding protein 17 (FBP17) interacts with sorting nexin, SNX2, and is an MLL -fusion partner in acute myelogeneous leukemiaSemantic proximity Read ↗

An In Vivo Topoisomerase II Cleavage Site and a DNase I Hypersensitive Site Colocalize Near Exon 9 in the MLLBreakpoint Cluster RegionSemantic proximity Read ↗

Fusion of the Leucine Zipper Gene <i>HLF</i> to the <i>E2A</i> Gene in Human Acute B-Lineage LeukemiaSemantic proximity Read ↗

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