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An In Vivo Topoisomerase II Cleavage Site and a DNase I Hypersensitive Site Colocalize Near Exon 9 in the MLLBreakpoint Cluster Region

15 Nov 1998

Abstract excerpt

The human myeloid-lymphoid leukemia gene, MLL (also called ALL-1, Htrx, or HRX ), maps to chromosomal band 11q23. MLL is involved in translocations that result in de novo acute lymphoblastic leukemia (ALL), acute myelogenous leukemia (AML), mixed lineage leukemia, and also in therapy AML (t-AML) and therapy ALL (t-ALL) resulting from treatment with DNA topoisomerase II (topo II) targeting drugs. MLL can recombine...

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PMID: 9808573
DOI: 10.1182/blood.v92.10.3793

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Related research

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An In Vivo Topoisomerase II Cleavage Site and a DNase I Hypersensitive Site Colocalize Near Exon 9 in the MLLBreakpoint Cluster RegionPMID 9808573Read ↗

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Genomic DNA breakpoints in <i>AML1</i> / <i>RUNX1</i> and <i>ETO</i> cluster with topoisomerase II DNA cleavage and DNase I hypersensitive sites in t(8;21) leukemiaSemantic proximity Read ↗

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DNA Cleavage within the<i>MLL</i>Breakpoint Cluster Region Is a Specific Event Which Occurs as Part of Higher-Order Chromatin Fragmentation during the Initial Stages of ApoptosisSemantic proximity Read ↗

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Rearrangements of the MLL gene in therapy-related acute myeloid leukemia in patients previously treated with agents targeting DNA- topoisomerase IISemantic proximity Read ↗

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