Article
Genome-wide detection of unknown subtle mutations in bacteria by combination of MutS and RDA.
Biochemical and biophysical research communications - 16 Feb 2000
Gotoh K, Hata M, Miyajima M, Yokota H
Abstract excerpt
We propose a procedure for detecting unknown, subtle DNA changes throughout the entire bacterial genome by a combination of MutS and RDA. Current techniques detect subtle mutations after PCR amplification of the target regions, so the mutation detection is done between amplified PCR fragments. In...
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