Removing the sampling restrictions from family-based tests of association for a quantitative-trait locus.

doi:10.1086/302745

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Article

Removing the sampling restrictions from family-based tests of association for a quantitative-trait locus.

American journal of human genetics - 1 Feb 2000

Monks S A, Kaplan N L

Abstract excerpt

One strategy for localization of a quantitative-trait locus (QTL) is to test whether the distribution of a quantitative trait depends on the number of copies of a specific genetic-marker allele that an individual possesses. This approach tests for association between alleles at the marker and the QTL, and it assumes that association is a consequence of the marker being physically close to the QTL. However,...

Topics

Alleles
Chromosome Mapping
Computer Simulation
False Positive Reactions
Female
Gene Dosage
Genetic Linkage
Genetic Markers
Genotype
Humans
Male
Mathematics
Models, Genetic
Nuclear Family
Quantitative Trait, Heritable
Reproducibility of Results
Sample Size
Statistics, Nonparametric

Source

Open in PubMed Open full text

Identifiers

PMID: 10677318
DOI: 10.1086/302745
PMCID: PMC1288111

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