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Article

Molecular cloning of Drosophila gamma-glutamylcysteine synthetase by functional complementation of a yeast mutant.

FEBS letters - 11 Feb 2000

Saunders R D, McLellan L I

Abstract excerpt

gamma-Glutamylcysteine synthetase (GCS) catalyses a critical, rate-limiting step in glutathione synthesis. In this study we describe the isolation and characterisation of a GCS cDNA (pDmGCS4.3. 3) from Drosophila melanogaster by functional complementation of a Saccharomyces cerevisiae gsh1 mutant. Expression of pDmGCS4.3.3 in the yeast mutant partially restored glutathione levels and conferred resistance to...

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PMID: 10675565
DOI: 10.1016/s0014-5793(00)01148-0

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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