Article
Insertion of a novel transposable element in the tyrosinase gene is responsible for an albino mutation in the medaka fish, Oryzias latipes.
Molecular & general genetics : MGG - 10 Dec 1995
Koga A, Inagaki H, Bessho Y, Hori H
Abstract excerpt
In the medaka fish (Oryzias latipes) many mutants for body color have been isolated. A typical example is the recessive oculocutaneous albino mutant i, which has amelanotic skin and red-colored eyes with no tyrosinase activity. To cast light on the molecular basis of the albino mechanism, we perf...
Topics
- Albinism
- Amino Acid Sequence
- Animals
- Base Sequence
- Blotting, Southern
- Cloning, Molecular
- DNA Probes
- DNA Transposable Elements
- Molecular Sequence Data
- Monophenol Monooxygenase
- Mutation
- Oryzias
- Repetitive Sequences, Nucleic Acid
- Restriction Mapping
- Sequence Analysis
- Sequence Homology, Nucleic Acid