Article
The Arg123-Tyr166 central domain of human ApoAI is critical for lecithin:cholesterol acyltransferase-induced hyperalphalipoproteinemia and HDL remodeling in transgenic mice.
Arteriosclerosis, thrombosis, and vascular biology - 1 Feb 2000
Holvoet P, De Geest B, Van Linthout S, Lox M, Danloy S, Raes K, Collen D
Abstract excerpt
High density lipoprotein (HDL) metabolism and lecithin:cholesterol acyltransferase (LCAT)-induced HDL remodeling were investigated in transgenic mice expressing human apolipoprotein (apo) AI or an apoAI/apoAII chimera in which the Arg123-Tyr166 domain of apoAI was substituted with the Ser12-Ala75 domain of apoAII. Expression of apoAI and of the apoAI/apoAII chimera resulted in a respective 3. 5-fold and 2.9-fold...
Topics
- Amino Acid Sequence
- Animals
- Apolipoprotein A-I
- Apolipoproteins
- Chimera
- Cholesterol, HDL
- Gene Transfer Techniques
- Genotype
- Humans
- Hyperlipoproteinemias
- Lipoproteins
- Lipoproteins, HDL
- Mice