Article
Human Y5 RNA specializes a Ro ribonucleoprotein for 5S ribosomal RNA quality control.
Genes & development - 1 Dec 2007
Hogg J Robert, Collins Kathleen
Abstract excerpt
Humans express four distinct non-protein-coding Y RNAs (ncRNAs). To investigate Y RNA functional diversification, we exploited an RNA-based affinity purification method to isolate ribonucleoproteins (RNPs) assembled on individual human Y RNAs. Silver staining and mass spectrometry revealed that the Ro and La proteins assemble with all Y RNAs, while additional proteins associate with specific Y RNAs. Unexpectedly,...
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