Article
Microsomal triglyceride transfer protein -493T variant reduces IDL plus LDL apoB production and the plasma concentration of large LDL particles.
American journal of physiology. Endocrinology and metabolism - 1 Apr 2006
Lundahl Björn, Skoglund-Andersson Camilla, Caslake Muriel, Bedford Dorothy, Stewart Philip, Hamsten Anders, Packard Christopher J, Karpe Fredrik
Abstract excerpt
The microsomal triglyceride transfer protein (MTP) is essential for the synthesis and secretion of apolipoprotein B (apoB)-containing lipoproteins. We investigated the role the MTP -493G/T gene polymorphism in determining the apoB-100 secretion pattern and LDL heterogeneity in healthy human subjects. Groups of carriers of the T and the G variants (n = 6 each) were recruited from a cohort of healthy 50-yr-old men....
Topics
- Adult
- Apolipoprotein B-100
- Apolipoproteins B
- Carrier Proteins
- Cohort Studies
- Genotype
- Humans
- Leucine
- Lipoproteins
- Lipoproteins, IDL
- Lipoproteins, LDL
- Male
- Middle Aged