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Article

Stability analysis for the cavity-filling mutations of the Myb DNA-binding domain utilizing free-energy calculations.

Proteins - 1 Feb 2000

Kono H, Saito M, Sarai A

Abstract excerpt

We have analyzed the effect of cavity-filling mutations on protein stability by means of free-energy calculations based on molecular dynamics simulations to identify the factors contributing to stability changes caused by the mutations. We have studied the DNA-binding domain of Myb, which has a cavity in one of three homologous repeat units, and analyzed a series of mutations with nonnatural and natural amino...

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Identifiers

PMID: 10656266
DOI: 10.1002/(sici)1097-0134(20000201)38:2<197::aid-prot8>3.0.co;2-b

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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