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Castration-Induced Apoptotic Cell Death in the Brown Norway Rat Prostate Decreases as a Function of Age1

1 Feb 2000

Abstract excerpt

Growth and differentiation of the prostate gland depends upon androgens, yet overgrowth of the human prostate occurs later in life when serum levels of testosterone are declining. We have reported a similar phenomenon in the Brown Norway rat, but the age-dependent overgrowth of the prostate is confined to the dorsal and lateral lobes and, hence, is lobe specific. Because tissue growth depends upon the balance...

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PMID: 10650965
DOI: 10.1210/endo.141.2.7339

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