Vacuolar H(+)-ATPase mutants transform cells and define a binding site for the papillomavirus E5 oncoprotein.

doi:10.1074/jbc.270.12.6830

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Article

Vacuolar H(+)-ATPase mutants transform cells and define a binding site for the papillomavirus E5 oncoprotein.

The Journal of biological chemistry - 24 Mar 1995

Andresson T, Sparkowski J, Goldstein D J, Schlegel R

Abstract excerpt

The 16K subunit of the vacuolar H(+)-ATPase binds specifically to the bovine (BPV) and human (HPV) papillomavirus E5 oncoproteins, and it has been suggested that this interaction may contribute to cell transformation (Goldstein, D. J., and Schlegel, R. (1990) EMBO J. 9, 137-146; Goldstein, D. J.,...

Topics

3T3 Cells
Animals
Binding Sites
Cell Transformation, Neoplastic
Mice
Mutation
Oncogene Proteins, Viral
Proton-Translocating ATPases
Structure-Activity Relationship
Transfection
Vacuoles

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