Article
The bromodomain protein LIN-49 and trithorax-related protein LIN-59 affect development and gene expression in Caenorhabditis elegans.
Development (Cambridge, England) - 1 Feb 2000
Chamberlin H M, Thomas J H
Abstract excerpt
We have molecularly characterized the lin-49 and lin-59 genes in C. elegans, and found their products are related to Drosophila trithorax group (trx-G) proteins and other proteins implicated in chromatin remodelling. LIN-49 is structurally most similar to the human bromodomain protein BR140, and LIN-59 is most similar to the Drosophila trx-G protein ASH1. In C. elegans, lin-49 and lin-59 are required for the...
Topics
- Adaptor Proteins, Signal Transducing
- Amino Acid Sequence
- Animals
- Animals, Genetically Modified
- Caenorhabditis elegans
- Caenorhabditis elegans Proteins
- Chromatin
- DNA-Binding Proteins
- Drosophila
- Drosophila Proteins
- Female
- Gene Expression Regulation, Developmental
- Genes, Helminth