Article
Applicability of a "speed" congenic strategy to dissect blood pressure quantitative trait loci on rat chromosome 2.
Hypertension (Dallas, Tex. : 1979) - 1 Jan 2000
Jeffs B, Negrin C D, Graham D, Clark J S, Anderson N H, Gauguier D, Dominiczak A F
Abstract excerpt
The identification of any quantitative trait locus (QTL) via a genome scan is only the first step toward the ultimate goal of gene identification. The next step is the production of congenic strains by which the existence of a QTL may be verified and the implicated chromosomal region be reduced to a size applicable to positional cloning of the causal gene. We used a speed congenic breeding protocol previously...
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