Article
Structural basis for recognition of the RNA major groove in the tau exon 10 splicing regulatory element by aminoglycoside antibiotics.
Nucleic acids research - 1 Feb 2000
Varani L, Spillantini M G, Goedert M, Varani G
Abstract excerpt
Drug-like molecules that bind RNA with sequence selectivity would provide valuable tools to elucidate gene expression pathways and new avenues to the treatment of degenerative and chronic conditions. Efforts at discovering such agents have been hampered, until recently, by the limited knowledge of RNA recognition principles. Several recent structures of aminoglycoside-RNA complexes have begun to reveal the...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.