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Mutation in the Magnesium Binding Site of hMSH6 Disables the hMutSα Sliding Clamp from Translocating along DNA

1 Jan 2000

Abstract excerpt

In human cells, binding of base/base mismatches and small insertion/deletion loops is mediated by hMutSalpha, a heterodimer of hMSH2 and hMSH6. In the presence of ATP and magnesium, hMutSalpha dissociates from the mismatch by following the DNA contour in the form of a sliding clamp. This process is enabled by a conformational change of the heterodimer, which is driven by the binding of ATP and magnesium in the...

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PMID: 10636912
DOI: 10.1074/jbc.275.3.2080

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Related research

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Research trail→

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Mutation in the Magnesium Binding Site of hMSH6 Disables the hMutSα Sliding Clamp from Translocating along DNAPMID 10636912Read ↗

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hMutSβ, a heterodimer of hMSH2 and hMSH3, binds to insertion/deletion loops in DNASemantic proximity Read ↗

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