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Article

Activation of human MutS homologs by 8-oxo-guanine DNA damage.

The Journal of biological chemistry - 8 Mar 2002

Mazurek Anthony, Berardini Mark, Fishel Richard

Abstract excerpt

The DNA lesion 8-oxo-guanine (8-oxo-G) is a highly mutagenic product of the interaction between reactive oxygen species and DNA. To maintain genomic integrity, cells have evolved mechanisms capable of removing this frequently arising oxidative lesion. Mismatch repair (MMR) appears to be one pathway associated with the repair of 8-oxo-G lesions (DeWeese, T. L., Shipman, J. M., Larrier, N. A., Buckley, N. M., Kidd,...

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Identifiers

PMID: 11756455
DOI: 10.1074/jbc.M111269200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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