Article
MALDI-TOF based mutation detection using tagged in vitro synthesized peptides.
Nature biotechnology - 1 Jan 2000
Garvin A M, Parker K C, Haff L
Abstract excerpt
Matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF) is a powerful method to quickly and accurately determine the masses of peptides. Most genetic analyses, however, begin with PCR amplification of a test sequence to generate DNA, which is more difficult than peptides to analyze by MALDI-TOF. We describe a method that produces a PCR product of any continuous region of coding...
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