Article
Signalling via receptor tyrosine kinase modulates the expression of the DNA repair enzyme XPD in cultured cells.
Molecular and cellular endocrinology - 25 Nov 1999
Perfetti R, Aggarwal S
Abstract excerpt
Oxidative damage to DNA has been documented in cells isolated from subjects with diabetes. Herein, we evaluate the mechanism(s) that regulate the expression of the DNA repair enzyme XPD. CHO cells transfected with the human insulin receptor (CHO/HIRc) showed a threefold increase in the level of XPD mRNA when compared to control CHO/neo cells (P < 0.01). The addition of insulin to serum-starved cells led to an...
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