Article
Protein interaction mapping in C. elegans using proteins involved in vulval development.
Science (New York, N.Y.) - 7 Jan 2000
Walhout A J, Sordella R, Lu X, Hartley J L, Temple G F, Brasch M A, Thierry-Mieg N, Vidal M
Abstract excerpt
Protein interaction mapping using large-scale two-hybrid analysis has been proposed as a way to functionally annotate large numbers of uncharacterized proteins predicted by complete genome sequences. This approach was examined in Caenorhabditis elegans, starting with 27 proteins involved in vulval development. The resulting map reveals both known and new potential interactions and provides a functional annotation...
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