Article
Cloning, functional characterisation and population analysis of a variant form of the human glycine type 2 transporter.
FEBS letters - 17 Dec 1999
Evans J, Herdon H, Cairns W, O'Brien E, Chapman C, Terrett J, Gloger I
Abstract excerpt
Two forms of glycine transporter have been described to date, GlyT-1 and GlyT-2. The GlyT-2 form is expressed mainly in the spinal cord, brainstem and cerebellum. Here we describe the identification of a variant form of the human GlyT-2 (SC6), showing three amino acid changes to the previously reported protein. Population analysis identified the allele causing one of the polymorphisms, D463N, at 10% within the...
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