Cytolethal distending toxin-producing Escherichia coli clinical isolates from Mexican children harbor different cdt types causing CDT-induced epithelial pathological phenotypes

Abstract excerpt

Abstract Cytolethal distending toxins (CDTs), encoded by cdtABC genes, have DNase activity leading to cellular and nuclear distention, resulting in actin remodeling, irreversible cell cycle arrest and apoptosis of target cells. PCR cdt -positive Escherichia coli strains have been isolated from children with diarrhea worldwide. However, toxin production and biological activity of cdt + strains are rarely...

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