Article
A -defensin mutation causes black coat color in domestic dogs.
Science (New York, N.Y.) - 30 Nov 2007
Candille Sophie I, Kaelin Christopher B, Cattanach Bruce M, Yu Bin, Thompson Darren A, Nix Matthew A, Kerns Julie A, Schmutz Sheila M, Millhauser Glenn L, Barsh Gregory S
Abstract excerpt
Genetic analysis of mammalian color variation has provided fundamental insight into human biology and disease. In most vertebrates, two key genes, Agouti and Melanocortin 1 receptor (Mc1r), encode a ligand-receptor system that controls pigment type-switching, but in domestic dogs, a third gene is implicated, the K locus, whose genetic characteristics predict a previously unrecognized component of the melanocortin...
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