Article
Genotypic analysis of Mycobacterium tuberculosis in two distinct populations using molecular beacons: implications for rapid susceptibility testing.
Antimicrobial agents and chemotherapy - 1 Jan 2000
Piatek A S, Telenti A, Murray M R, El-Hajj H, Jacobs W R, Kramer F R, Alland D
Abstract excerpt
Past genotypic studies of Mycobacterium tuberculosis may have incorrectly estimated the importance of specific drug resistance mutations due to a number of sampling biases including an overrepresentation of multidrug-resistant (MDR) isolates. An accurate assessment of resistance mutations is crucial for understanding basic resistance mechanisms and designing genotypic drug resistance assays. We developed a rapid...
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