Article
DQB1*0602 confers genetic susceptibility to multiple sclerosis in Afro-Brazilians.
Tissue antigens - 1 Nov 1999
Caballero A, Alvés-León S, Papais-Alvarenga R, Fernández O, Navarro G, Alonso A
Abstract excerpt
We studied the distribution of the HLA-DRB1, -DQA1 and -DQB1 alleles in 44 Afro-Brazilian patients with multiple sclerosis and 88 controls. Although no significant differences were found between the patients and controls for the DRB1 and DQA1 alleles, the HLA-DQB1*0602 allele was positively associated with multiple sclerosis (45.0% vs. 17.0%, Pc=0.024, RR=3.31). The positive extended haplotypes for DQB1*0602 were...
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