Article
Preimplantation diagnosis of the beta1 integrin knockout mutation as a model for aneuploid gene testing.
Human genetics - 1 Nov 1999
Kim H S, Klimanskaya I V, Damsky C K, Pedersen R A, Lebo R V
Abstract excerpt
The autosomal beta1 integrin knockout mouse mutation was selected as a model to experimentally determine preimplantation diagnosis test reliability for autosomal gene deletions and duplications. In experiment 1, which analyzed 198 individually disaggregated single blastomeres, the observed test frequencies matched the mathematically predicted frequencies calculated from the independently derived values of 90%...
Topics
- Aneuploidy
- Animals
- Base Sequence
- Blastomeres
- DNA Primers
- Embryonic Development
- Female
- Genetic Diseases, Inborn
- Genotype
- Humans
- Integrin beta1
- Male
- Mice
- Mice, Knockout
- Models, Genetic
- Mutation
- Phenotype
- Pregnancy