Article
Concurrent Preimplantation Genetic Testing and Competence Assessment of Human Embryos by Transcriptome Sequencing.
Advanced science (Weinheim, Baden-Wurttemberg, Germany) - 1 Aug 2024
Wang Yuqian, Li Ye, Zhu Xiaohui, Yang Ming, Liu Yujun, Wang Nan, Long Chuan, Kuo Ying, Lian Ying, Huang Jin, Jia Jialin, Wong Catherine C L, Yan Zhiqiang, Yan Liying, Qiao Jie
Abstract excerpt
Preimplantation genetic testing (PGT) can minimize the risk of birth defects. However, the accuracy and applicability of routine PGT is confounded by uneven genome coverage and high allele drop-out rate from existing single-cell whole genome amplification methods. Here, a method to diagnose genetic mutations and concurrently evaluate embryo competence by leveraging the abundant mRNA transcript copies present in...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.