Article
Family density of alcoholism and linkage information in the analysis of the COGA data.
Genetic epidemiology - 1 Jan 1999
Turecki G, Rouleau G A, Alda M
Abstract excerpt
In this study of GAW11 Problem 1, we analyzed the genome scan data in families weighted according to the density of alcoholism among the probands' siblings. We hypothesized that certain disease-predisposing alleles may be common in the general population, rendering high-density sibships less informative for linkage. Three types of families were found in the data, with the prevalence of alcoholism of 1.0, 0.78,...
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