Article
Comparison of empirical strategies to maximize GENEHUNTER lod scores.
Genetic epidemiology - 1 Jan 1999
Chen C H, Finch S J, Mendell N R, Gordon D
Abstract excerpt
We compare four strategies for finding the settings of genetic parameters that maximize the lod scores reported in GENEHUNTER 1.2. The four strategies are iterated complete factorial designs, iterated orthogonal Latin hypercubes, evolutionary operation, and numerical optimization. The genetic parameters that are set are the phenocopy rate, penetrance, and disease allele frequency; both recessive and dominant...
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