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Article

Optic, olfactory, and vestibular dysmorphogenesis in the homozygous mouse insertional mutant Tg9257.

Journal of craniofacial genetics and developmental biology - 1 Jan 2000

Griffith A J, Ji W, Prince M E, Altschuler R A, Meisler M H

Abstract excerpt

The transgene insertional mutation 9257 on mouse chromosome 18 was originally identified by the circling behavior caused by vestibular abnormalities in heterozygous mutants. To characterize the homozygous phenotype, we generated F2 offspring from the cross (C57BL/6J-tg/+ x DBA/2J). Eye defects ranging in severity from microphthalmia to anophthalmia were observed in the tg/tg offspring. Dysmorphic development of...

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PMID: 10589397

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