Article
A new mouse insertional mutation that causes sensorineural deafness and vestibular defects.
Genetics - 1 Aug 1999
Alagramam K N, Kwon H Y, Cacheiro N L, Stubbs L, Wright C G, Erway L C, Woychik R P
Abstract excerpt
This article describes a new recessive insertional mutation in the transgenic line TgN2742Rpw that causes deafness and circling behavior in mice. Histologic analysis revealed virtually complete loss of the cochlear neuroepithelium (the organ of Corti) in adult mutant mice. In association with the neuroepithelial changes, there is a dramatic reduction of the cochlear nerve supply. Adult mutants also show...
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