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Article

Metal binding and activation of the ribonuclease H domain from moloney murine leukemia virus.

Protein engineering - 1 Nov 1999

Goedken E R, Marqusee S

Abstract excerpt

The RNase H family of enzymes degrades RNA in RNA.DNA hybrids in a divalent cation-dependent manner. RNases H from diverse sources such as Escherichia coli and human immunodeficiency virus (HIV) share homologous metal-binding active sites, and the activity of the RNase H domain of reverse transcriptase (RT) is required for retroviral replication. The isolated RNase H domain from HIV RT, however, is inactive. In...

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PMID: 10585503
DOI: 10.1093/protein/12.11.975

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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