Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

An Sp1 binding site is essential for basal activity of the human prostate-specific transglutaminase gene (TGM4) promoter.

Gene - 29 Nov 1999

Dubbink H J, Cleutjens K B, van der Korput H A, Trapman J, Romijn J C

Abstract excerpt

Human prostate-specific transglutaminase (hTG(P)) is a cross-linking enzyme encoded by the TGM4 gene. The TGM4 gene promoter was characterized by deletion mapping and mutational analysis. Promoter constructs, containing the minimal promoter requirements, could efficiently drive transcription in the prostate cancer cell lines PC346C and LNCaP and the hepatic cancer cell line Hep3B. The region between positions...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Binding, Competitive
Share to Electrophoresis, Polyacrylamide Gel

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Luciferases

Share to Prostate

Share to Sequence Deletion

Share to Sp1 Transcription Factor

Share to Sp3 Transcription Factor

Share to Transglutaminases

Source

Identifiers

PMID: 10580145
DOI: 10.1016/s0378-1119(99)00454-0

Genes

TGM4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

An Sp1 binding site is essential for basal activity of the human prostate-specific transglutaminase gene (TGM4) promoter.PMID 10580145Read ↗

HGSNAT has a TATA-less promoter with multiple starts of transcription.Semantic proximity Read ↗

Hypermethylation trigger of the glutathione-S-transferase gene (GSTP1) in prostate cancer cells.Semantic proximity Read ↗

A distal region of the human TGM1 promoter is required for expression in transgenic mice and cultured keratinocytes.Semantic proximity Read ↗

Multiple Sp1 sites efficiently drive transcription of the TATA-less promoter of the human glypican 3 (GPC3) gene.Semantic proximity Read ↗

Functional characterization of the proximal promoter of the murine pyruvate carboxylase gene in hepatocytes: role of multiple gc boxes.Semantic proximity Read ↗

The human glutathione transferase alpha locus: genomic organization of the gene cluster and functional characterization of the genetic polymorphism in the hGSTA1 promoter.Semantic proximity Read ↗

Promoter of the gene for the multifunctional protein disulfide isomerase polypeptide. Functional significance of the six CCAAT boxes and other promoter elements.Semantic proximity Read ↗

Functional characterization of cis- and trans-regulatory elements involved in expression of phospholipid hydroperoxide glutathione peroxidase.Semantic proximity Read ↗

Role of the functional variant (-652T>G) in the XRCC4 promoter in prostate cancer.Semantic proximity Read ↗

Regulation of transcription of the murine gamma-glutamyl hydrolase gene. Delineation of core promoter A and the role of LYF-1, E2F and ETS-1 in determining tumor-specific expression.Semantic proximity Read ↗

Specific protein-1 is a universal regulator of UDP-glucose dehydrogenase expression: its positive involvement in transforming growth factor-beta signaling and inhibition in hypoxia.Semantic proximity Read ↗

Partial characterisation of the human GFAT promoter: effect of single nucleotide polymorphisms on promoter function.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.